Job Title
Postdoctoral Fellow – Vinuesa Lab
Salary
From £47,500 + benefits subject to skills and experience.
Closing Date
01/Jun/2026 23.59 GMT
Reporting
Reports to Carola Vinuesa, Principal Group Leader – Assistant Research Director
Working Pattern
Full-time, 4 year fixed term position on Crick terms and conditions of employment.
About the Laboratory
The Dr Vinuesa’s laboratory focuses on understanding protective antibody responses and mechanisms underpinning antibody‑mediated diseases, targeting autoimmune and allergic diseases.
Project
The role studies triggers of TLR7 signalling in autoimmunity using a mouse model with a rare TLR7 gain‑of‑function variant.
Responsibilities
- Undertake own research project and independently design and perform experiments on triggers of TLR7 signalling.
- Manage mouse colony and conduct in‑vivo experiments.
- Conduct single‑cell BCR‑seq and clonal analysis via bioinformatic pipelines.
- Provide scientific and technical support to group members.
- Manage data, analyse, write manuscripts.
- Present at scientific meetings.
- Guide PhDs in research.
Qualifications
- PhD in Immunology or final stages of PhD submission.*
- Experience in mouse models of immunology (vaccination, allergy, autoimmunity).
- Experience with mouse husbandry, sampling, and processing.
- Expertise in B cell biology including germinal centre responses, plasma cell biology, class switch recombination, somatic hypermutation.
- Experience in BCR sequencing and clonal analysis.
- Experience in mucosal immunology and mucosal B cell responses.
- Strong track record of high‑quality research with first author publications in peer‑reviewed journals.
EEO Statement
We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. The Francis Crick Institute is a Disability Confident employer and will make reasonable adjustments if needed.
Benefits
- Visas: eligibility for sponsorship.
- Annual leave: 28 days + three additional days over Christmas and bank holidays.
- Pension scheme: defined contribution pension with employer contributions up to 16%.
- Health & Well‑being: 24/7 GP consultation, occupational health, mental health support, eye care vouchers, healthcare plan discounts.
- Work‑Life Balance: backup care for dependents, childcare support allowance, annual leave purchase options.
- Perks: discounted gym memberships, bike‑to‑work scheme, shopping discounts, subsidised on‑site restaurant and social spaces.
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