Skin Bioassay Senior Scientist
Nottingham | On-site
We are seeking a Skin Bioassay Senior Scientist to join a growing CRO environment developing advanced in vitro skin models and bioassays for both pharmaceutical and cosmetic applications.
This role is part of a strategic expansion of in‑house skin capabilities, supporting both ongoing projects and the development of new model systems. You will play a key role in generating high‑quality datasets, developing human‑relevant skin models, and delivering impactful assay results for clients.
Working within a collaborative, fast‑paced laboratory environment, you will contribute to the development of next‑skin models, including reconstructed and full‑thickness systems, while supporting a broad range of client‑driven and internal projects.
Responsibilities
Skin Model Development
- Develop and optimise in vitro skin models, including:
- Reconstructed Human Epidermis (RHE) models
- Full‑thickness or full‑skin equivalent systems
- Contribute to the evolution of increasingly complex, physiologically relevant models
Assay Development & Delivery
- Design and execute cosmetic and skin‑related bioassays, including:
- Cell proliferation and viability assays
- Cytokine release and inflammatory markers
- Barrier function and sensitivity assessments
- Analyse and interpret experimental data, ensuring robust, client‑ready datasets
Molecular & Analytical Techniques
- Apply a range of techniques including:
- ELISA and immunoassays
- qPCR and molecular biology workflows
- Plate‑based assay readouts
- Use imaging and histology‑based approaches to assess skin structure and function
Applied Skin Science & Testing
- Evaluate cosmetic formulations and active compounds
- Investigate:
- Ageing processes and protective effects
- UV response (using in‑house UV systems)
- Key skin proteins such as keratin and structural markers
Project Delivery & Lab Operations
- Deliver experimental work in line with project timelines and client expectations
- Prepare SOPs, reports, and technical documentation
- Troubleshoot experiments and contribute to continuous improvement initiatives
- Support a collaborative CRO environment including potential client interaction
About You
You are a hands‑on scientist with experience in skin biology and in vitro model systems, comfortable working in a fast‑paced, applied research or CRO environment.
You’ll bring:
- Experience working with in vitro skin models (essential)
- Experience developing RHE (Reconstructed Human Epidermis) models
- Strong laboratory experience across cell‑based assays and bioassays
- Knowledge of ELISA, immunoassays, qPCR, and cell culture techniques
- A practical, delivery‑focused mindset with strong attention to detail
Highly desirable
- Exposure to full‑skin equivalent or 3D skin models
- Experience in cosmetic testing, skin ageing, or UV response studies
- Background in CROs or applied commercial research
PhD candidates or those with 2–3 years of relevant industry experience are both encouraged to apply.
This is a great opportunity to join a growing organisation at a key stage, where you will not only deliver projects but also help shape the future direction of skin model development within the business.
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