PE Global is currently recruiting for a Protein Crystallographer on behalf of a leading global biopharmaceutical organisation on a 12-month contract basis.
Based at a state-of-the-art research facility in Bracknell, this hybrid contract role will suit an experienced structural biologist with a strong background in protein crystallography and fragment-based ligand discovery (FBLD).
- Location: Bracknell, Berkshire
- Working Pattern: Hybrid (2 days per week on site)
- Rate: £28.54 – £38.01 per hour depending on experience.
***Please note our client cannot assist with any visa sponsorship, and candidates must have the correct visa to live and work in UK for at least 12 months***
Key Responsibilities
- Utilise low-occupancy crystallography software and standard refinement packages to efficiently model and refine outputs from crystallographic fragment screening campaigns.
- Coordinate X-ray data collection activities using internal synchrotron resources, external synchrotron facilities, and contract research organisations (CROs).
- Design, execute, and analyse fragment screening experiments using X-ray crystallography.
- Collaborate with internal and external scientific partners to develop cutting-edge crystallography methods, including approaches for identifying and characterising cryptic binding pockets.
- Support fragment progression through iterative design cycles, including fragment growth, linking, and merging strategies.
- Process and interpret large volumes of crystallographic datasets in parallel.
- Contribute to the continuous improvement of structural biology workflows, automation, and data quality standards.
Required Experience & Qualifications
- PhD in Structural Biology, Biochemistry, Chemical Biology, Chemistry, or a related scientific discipline.
- Significant hands-on experience in protein crystallography, including solving large numbers of protein-fragment crystal structures and processing extensive datasets in parallel.
- Demonstrable experience delivering fragment screening campaigns using X-ray crystallography.
- Strong expertise with crystallography software including PHENIX and BUSTER.
- Experience using FBLD-related software (Maestro/Schrödinger, ICM-Pro, GINGER, FrankenROCS, Fragmentstein, cluster4x, PanDDA)
- Experience scripting and automating crystallography workflows, ideally within a High-Performance Computing (HPC) environment.
Interested candidates should submit an updated CV. Please click the link below to apply.
***Please note our client cannot assist with any visa sponsorship, and candidates must have the correct visa to live and work in UK***
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