Clinical Informatician (Senior Cancer RWD Analyst)

Guy’s and St Thomas’ NHS Foundation Trust

Clinical Informatician (Senior Cancer RWD Analyst)

The closing date is 21 July 2026

This is an exciting opportunity to take a key role in the AI Centre for Value-Based Healthcare, working with the Guy’s Cancer Real-World Evidence (RWE) team. The post-holder will curate and develop regulatory-grade, deep cancer data assets, ensuring that outputs are clinically meaningful, aligned with research and commercial needs, and grounded in real-world cancer care delivery.

Responsibilities

• Curate and develop regulatory-grade deep cancer data assets, primarily thoracic cancers, defining and validating cohort logic, variables, and derived endpoints
• Oversee clinical validation of NLP-derived features extracted from unstructured records (clinical letters, radiology, pathology, MDT) and feed back into pipeline improvement
• Act as the clinical-informatics bridge between AI Centre data engineers and the Guy’s Cancer RWE team, translating among clinical, scientific, and engineering audiences
• Take analytical lead on complex cancer data, devising methods, setting data-quality KPIs, and providing evidence-based recommendations to stakeholders
• Engage and influence clinical, academic and commercial partners, contributing to research outputs and longer-term strategic partnerships
• Lead and mentor within matrixed project teams, supporting capability building and effective use of resources
• Produce documentation on data provenance, derivation logic and quality for regulatory compliance
• Create standardised, tested, provenanced cancer datasets for research and commercial delivery
• Enable the thoracic RWE team to deliver international academic collaborations (e.g., IASLC)
• Develop analytic tools, datasets and insights supporting business planning, decision-making and research prioritisation across the RWD/RWE programme
• Evaluate and analyse highly complex cancer data, identifying root causes of data-quality issues and opportunities for improvement
• Determine and track KPIs for depth, coverage and quality of cancer data assets, working with clinical leads and operational teams
• Manage analytical projects from inception to completion, working autonomously and demonstrating a leadership style consistent with the Trust values

Qualifications

• Clinical background with an understanding of the oncology domain
• Understanding of cancer clinical research, pharma studies/clinical trials, and regulatory requirements for RWD/RWE in oncology
• Expertise in clinical data and informatics, including source systems and oncology-specific vocabularies
• Proficiency in SQL and Python (+/- R) for engineering and analysing datasets, validating cohort definitions, and generating insights and visualisations
• Experience building or working with cloud data platforms (e.g., Snowflake)
• Experience overseeing clinical validation of NLP-derived features from unstructured medical records
• Track record of high-impact research output and/or commercial partnership delivery in RWE
• Excellent stakeholder engagement skills, translating between engineering, clinical and scientific audiences
• Excellent project management skills

Disclosure and Barring Service Check

This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions.

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