Senior or Principal Scientist – 3D Molecular Modelling
Founded in 2009 and headquartered in Cambridge, UK, Optibrium develops software and novel technologies to improve the efficiency and productivity of drug discovery. Our solutions support industry-leading research for a global customer base, including top ten pharma and innovative biotech companies.
Optibrium software solutions include:
- StarDrop ™ – A complete package of fully integrated software for multi-objective small molecule design, optimisation, and data analysis;
- Cerella ™ – A unique platform for the imputation of drug discovery data, revealing insights into the best compounds and most valuable experiments;
- BioPharmics ™ – A fast, robust, and accurate 3D ligand- and structure-based design platform that scales from small molecules to large macrocycles.
With a strong track record of translating peer‑reviewed science into successful products and a growing blue‑chip customer base for BioPharmics, we are recruiting a Senior or Principal Scientist – 3D Molecular Modelling to help customers achieve challenging drug discovery objectives and maximise the value of our software.
About the Role
As a Senior or Principal Scientist you will:
- Apply 3D structure‑based and ligand‑based design approaches to lead discovery and optimisation
- Support current and prospective customers in the effective use of BioPharmics, working with the commercial team to communicate its value clearly and scientifically
- Use NMR and X‑ray crystallography data in combination with the BioPharmics modelling methods
- Provide guidance on the development of the BioPharmics platform by identifying unmet customer needs and translating them into product and research opportunities
- Represent Optibrium’s science and products at conferences, workshops, and customer meetings
About You
The ideal candidate will have the following experience:
- PhD in computational chemistry, computer science, chemistry, biophysics, or a related discipline
- Strong understanding of structure‑based and ligand‑based drug design, ideally including experience with macrocycles and peptides
- Experience with molecular modelling and visualisation platforms, e.g., PyMOL and MOE
- Experience with structural data (NMR and X‑ray crystallography) applied to molecular design problems
- A track record of high‑quality peer‑reviewed publications and conference presentations
- The ability to work effectively with customers, collaborators, and cross‑functional teams
What We Offer
We offer hybrid & flexible working, a competitive base salary, pension contribution, employee private medical and dental cover, life assurance, corporate gym discount and cycle to work scheme.
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