Senior Scientist (DMPK) – 12‑month FTC – Cambridge
Key Responsibilities
- Develop and evolve an appropriate DMPK screening cascade aligned to project stage and objectives.
- Design, execute and interpret in vitro ADME assays, communicating results clearly to project team members.
- Oversee CRO activities including compound submissions, experiment tracking, and timely communication of data updates.
- Prepare and maintain slide decks and documentation summarising CRO outputs and project progress; manage purchase orders and invoicing related to CRO work.
- Maintain accurate, complete and up‑to‑date electronic laboratory notebooks in line with internal standards.
- Perform LC‑MS/MS analyses for small and large molecules, including routine maintenance and basic troubleshooting.
Key Requirements
- PhD or BSc/MSc with relevant experience in a life sciences discipline, plus industrial drug discovery experience.
- Practical knowledge of in vitro ADME assays including microsomal stability, hepatocyte stability, protein binding and permeability.
- Experience using Phoenix WinNonlin.
- Knowledge and prior experience of metabolite identification.
- Strong time management, excellent written and verbal communication skills, and the ability to build effective relationships with internal and external partners.
- Experience advancing discovery programs from Lead Optimisation (LO) through candidate selection.
- Knowledge of PK‑PD and/or PBPK modelling and human dose prediction.
- Practical experience in bioanalysis by LC‑MS/MS.
- Experience with MassLynx and/or UNIFI.Guidant, Carbon60, Lorien & SRG.
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