Director, Clinical Pharmacology
The Department of Clinical Pharmacology Modelling & Simulation Respiratory and Inflammation (CPMS R&I) at GSK is recruiting a director-level Clinical Pharmacologist. The role is based in the UK or US, with remote working or placement at other European GSK sites possible for the right candidate.
Job Purpose
The Director, Clinical Pharmacology sits within the newly established Clinical Pharmacology and Quantitative Medicine (CPQM) organisation and aims to be a centre of excellence in Model‑Informed Drug Development (MIDD) by integrating clinical pharmacology, digital medicine, translational imaging and mechanistic/systems modelling. You will lead the end‑to‑end application of MIDD across the drug development lifecycle—from first‑in‑human studies through filing and lifecycle management—and provide clinical pharmacology strategy and evidence-generation input.
Main Responsibilities
- Design & Execute Model Informed and Clinical Pharmacology strategies: Develop and implement robust MIDD & ClinPharm evidence strategies to de‑risk and accelerate RIIRU programs, with a focus on faster development, optimal dosing and stronger regulatory positioning across respiratory, inflammation, neurodegeneration and emerging areas.
- Ensure robust ways of working and regulatory‑ready evidence: Draft and review clinical pharmacology regulatory content to support timely approvals and optimal labelling; maintain up‑to‑date knowledge of FDA, EMA, CDE, PMDA and ICH expectations and embed regulatory considerations into study design and MIDD strategies.
- Build cross‑functional partnerships: Work closely with CPQM peers (digital medicine, translational imaging, MIDD specialists, mechanistic/systems modelling) and cross‑functional partners (biology, data science, computational biology, clinical, etc.). Maintain strong networks and share best practices in the CPMS community of practice; collaborate with key functions such as AI/ML, biomarkers, biostatistics, clinical operations, data science, computational biology and RWE.
- External engagement & scientific leadership: Raise GSK’s profile in MIDD, clinical pharmacology, QSP and AI/ML integration through publications, conference presentations and active participation in scientific and regulatory fora.
Basic Qualifications
- PhD in life sciences or related discipline, MD or PharmD with experience in clinical pharmacology, modelling and simulation in pharmaceutical research and development.
- Significant experience in clinical pharmacology, modelling/simulation and drug development to solve practical problems in the pharmaceutical industry.
- Experience in pharmacometrics and their application to clinical questions in drug development.
Preferred Qualifications
- Additional experience in respiratory and immunology would be beneficial.
- Demonstrated collaboration in a multi-discipline team, using effective communication and taking personal accountability for timely delivery of results.
- Evidenced experience making sound judgement in complex situations and adapting to changing business needs by prioritizing multiple tasks.
- Experience working with senior stakeholders in a cross‑functional environment.
- Track record of implementation of MIDD approaches to accelerate patient access to novel therapies and to expand therapeutic indications of marketed drugs.
- Drive and learning agility to build knowledge on a drug‑disease system, symptom progression, standard of care and trial design.
Salary and Benefits
For US candidates in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary ranges from $188,100 to $313,500. The position offers an annual bonus, eligibility to participate in a share‑based long‑term incentive program and benefits including health care, retirement, paid holidays, vacation and paid caregiver/parental and medical leave.
#J-18808-Ljbffr”, “datePosted”: “2026-05-01”, “hiringOrganization”: { “@type”: “Organization”, “name”: “WISE Campaign”, “sameAs”: “https://uk.whatjobs.com/pub_api__cpl__419930010__4861?utm_campaign=publisher&utm_medium=api&utm_source=4861&geoID=33” }, “jobLocation”: { “@type”: “Place”, “address”: { “@type”: “PostalAddress”, “addressLocality”: “London” } } }Director, Clinical Pharmacology
The Department of Clinical Pharmacology Modelling & Simulation Respiratory and Inflammation (CPMS R&I) at GSK is recruiting a director-level Clinical Pharmacologist. The role is based in the UK or US, with remote working or placement at other European GSK sites possible for the right candidate.
Job Purpose
The Director, Clinical Pharmacology sits within the newly established Clinical Pharmacology and Quantitative Medicine (CPQM) organisation and aims to be a centre of excellence in Model‑Informed Drug Development (MIDD) by integrating clinical pharmacology, digital medicine, translational imaging and mechanistic/systems modelling. You will lead the end‑to‑end application of MIDD across the drug development lifecycle—from first‑in‑human studies through filing and lifecycle management—and provide clinical pharmacology strategy and evidence-generation input.
Main Responsibilities
- Design & Execute Model Informed and Clinical Pharmacology strategies: Develop and implement robust MIDD & ClinPharm evidence strategies to de‑risk and accelerate RIIRU programs, with a focus on faster development, optimal dosing and stronger regulatory positioning across respiratory, inflammation, neurodegeneration and emerging areas.
- Ensure robust ways of working and regulatory‑ready evidence: Draft and review clinical pharmacology regulatory content to support timely approvals and optimal labelling; maintain up‑to‑date knowledge of FDA, EMA, CDE, PMDA and ICH expectations and embed regulatory considerations into study design and MIDD strategies.
- Build cross‑functional partnerships: Work closely with CPQM peers (digital medicine, translational imaging, MIDD specialists, mechanistic/systems modelling) and cross‑functional partners (biology, data science, computational biology, clinical, etc.). Maintain strong networks and share best practices in the CPMS community of practice; collaborate with key functions such as AI/ML, biomarkers, biostatistics, clinical operations, data science, computational biology and RWE.
- External engagement & scientific leadership: Raise GSK’s profile in MIDD, clinical pharmacology, QSP and AI/ML integration through publications, conference presentations and active participation in scientific and regulatory fora.
Basic Qualifications
- PhD in life sciences or related discipline, MD or PharmD with experience in clinical pharmacology, modelling and simulation in pharmaceutical research and development.
- Significant experience in clinical pharmacology, modelling/simulation and drug development to solve practical problems in the pharmaceutical industry.
- Experience in pharmacometrics and their application to clinical questions in drug development.
Preferred Qualifications
- Additional experience in respiratory and immunology would be beneficial.
- Demonstrated collaboration in a multi-discipline team, using effective communication and taking personal accountability for timely delivery of results.
- Evidenced experience making sound judgement in complex situations and adapting to changing business needs by prioritizing multiple tasks.
- Experience working with senior stakeholders in a cross‑functional environment.
- Track record of implementation of MIDD approaches to accelerate patient access to novel therapies and to expand therapeutic indications of marketed drugs.
- Drive and learning agility to build knowledge on a drug‑disease system, symptom progression, standard of care and trial design.
Salary and Benefits
For US candidates in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary ranges from $188,100 to $313,500. The position offers an annual bonus, eligibility to participate in a share‑based long‑term incentive program and benefits including health care, retirement, paid holidays, vacation and paid caregiver/parental and medical leave.
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