Genomics England is a global leader in enabling genomic medicine and research, focused on creating a world where everyone benefits from genomic healthcare. Building on the 100,000 Genomes Project, we support the NHS’s world-first national whole genome sequencing service and run the growing National Genomic Research Library, alongside delivering numerous major genomics initiatives. By connecting research and clinical care at national scale, we enable immediate healthcare benefits and advances for the future.
Our mission is to provide the evidence and digital systems so that by 2035 genomics could play a role in up to half of all healthcare interactions, whilst securing the UK’s position as the best place to discover, prove and benefit from genomic innovations.
We are accelerating our impact and working with patients, doctors, scientists, government and industry to improve genomic testing, and help researchers access the health data and technology they need to make new medical discoveries and create more effective, targeted medicines for everybody.
Behind the Healthcare and Research outcomes, Genomics England delivers through designing, developing and operating complex healthcare software systems.
We’re on the cusp of big changes with the real prospect of genomics becoming the fabric of everyday healthcare through the lifetime – from birth to old age.
Job Description
We are seeking a Bioinformatics Engineer to help develop andscale knowledgeplatforms that underpin the NHS Whole Genome Sequencing (WGS) Genomic Medicine Service, includingPanelAppandCellBase. These systems arekeytoclinical impact, by enablingmanagement of the latestvariant annotation data as well ascuration,validationand delivery ofgene–disease relationshipsinto clinical pipelines across the NHS.
You will work onbig dataproduction systems spanning Python-based services and Java-backedplatforms,building APIs, data models, and pipelines that deliver high-quality, clinically relevant genomic knowledge at scale.
In this role, you will collaborate closely withgenomic data scientists,curators,engineersand pipeline teams to translate evolving clinical requirements into robust, testable software suitable for use in a regulated environment. You will take ownership of system design, implementation, and data integrity, ensuring that our platformsremainreliable, performant, and clinically trustworthy.
You will work within an agile team to deliver and continuously improve production systems, contributing to engineering standards and shaping how we build. Asabioinformatics specialist in the team, you will guide design decisions and ensure that clinical and biological context is accurately reflected in the software.
Everyday responsibilities include:
- Produce high-quality code forhigh throughput sequencing data analysis, genome analysis,workflowsand interpretation.
- Interact with domain experts during the lifecycle of projects to ensure the scientific validity of software products.
- Contributetodiscoverytasksduringtheinitialphaseofnewdevelopments and achieve understanding of early-stage decisions to inform final software design.
- Produce automated tests tovalidateexisting and new code.
- Contribute to all testing and deployment stages up to the production environment.
- Writedocumentationtoachieveanexhaustivelogofdecisions,designs, tests,resultsetc.thatenablefulltraceabilityofprocesses.
- Beaproactivememberofasquad,adoptingagilepractices and offering subject matterexpertise.
- Ensureadherencetothevariousstandardsandaccreditationsrequiredfor both clinicallaboratorypracticeandsoftwaredelivery.
Skills and experience for success
- Strong Python development skills, including writing production code, tests, and working with modern libraries and tooling.
- Experience designing andmaintainingproduction systems such as APIs, data pipelines, ordata‑backedservices.
- Experience with collaborative development workflows (Git, code review, branching strategies) and CI/CD pipelines.
- Experience working with genomic or other biological datasets and the associated standards and data models (for example gene/transcript models, variants, ontologies).
- Experience integrating andvalidatingheterogeneous biological datasets (e.g.Ensembl,ClinVar,gnomAD, in silico predictors), including ingestion, harmonisation, and checking that downstream query results are complete and biologically or clinically meaningful.
- Ability to assess and ensure data quality, includingidentifyinginconsistencies, designing checks to confirm completeness of data ingestion, andvalidatingthat system outputs areaccurateand clinicallyappropriate.
- Programming experience with Javaservices.
- Experience with genomic variant annotation, gene–disease curation systems, or clinical knowledgebases.
Qualifications
MSc equivalent or higher in Software Engineering, Computer Science, Bioinformatics or equivalent experience.
Additional Information
Salary from: £56,000
Closing date for applications – Friday 22nd May
Benefits
- Generous Leave: 30 days’ holiday plus bank holidays, additional leave for long service, and the option to apply for up to 30 days of remote working abroad annually (approval required).
- Family-Friendly: Blended working arrangements, flexible working, enhanced maternity, paternity and shared parental leave benefits.
- Pension & Financial: Defined contribution pension (Genomics England double-matches up to 10%, however you can contribute more if you wish), Life Assurance (3x salary), and a Give As You Earn scheme.
- Learning & Development: Individual learning budgets, support for training and certifications, and reimbursement for one annual professional subscription (approval required).
- Recognition & Rewards: Employee recognition programme and referral scheme.
- Health & Wellbeing: Subsidised gym membership, a free Headspace account, and access to an Employee Assistance Programme, eye tests, flu jabs.
Equal opportunities and our commitment to a diverse and inclusive workplace
Genomics England is actively committed to providing and supporting an inclusive environment that promotes equity, diversity and inclusion best practice both within our community and in any other area where we have influence. We are proud of our diverse community where everyone can come to work and feel welcomed and treated with respect regardless of any disability, ethnicity, gender, gender identity, religion, sexual orientation, or social background.
Genomics England’s policies of non-discrimination and equity and will be applied fairly to all people, regardless of age, disability, gender identity or reassignment, marital or civil partnership status, being pregnant or recently becoming a parent, race, religion or beliefs, sex or sexual orientation, length of service, whether full or part-time or employed under a permanent or a fixed-term contract or any other relevant factor.
Genomics England does not tolerate any form of discrimination, harassment, victimisation or bullying at work. Such behaviour undermines our mission and core values and diminishes the dignity, respect and integrity of all parties. Our People policies outline our commitment to inclusivity.
We aim to remove barriers in our recruitment processes and to be flexible with our interview processes. Should you require any adjustments that may help you to fully participate in the recruitment process, we encourage you to discuss this with us.
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