Postdoctoral Scientist
Salary £42,694 per annum; Fixed term, 3 years; MRC Laboratory of Molecular Biology, Cambridge, UK.
Overview
To work in the group of Dr Michel Goedert from the Neurobiology Division of the MRC Laboratory of Molecular Biology (LMB), as part of a programme aimed at understanding Molecular Mechanisms of Neurodegeneration. Specifically, to undertake research to develop methods for forming alpha‑synuclein filaments with the same structures as those from human brain. This work will be done in close collaboration with the group of Dr Sjors Scheres from the Structural Studies Division of the LMB.
Responsibilities
- Develop methods for forming alpha‑synuclein filaments that mimic the structures observed in human brains.
- Use electron cryo‑microscopy (cryo‑EM) to determine filament folds and investigate disease‑specific structures.
- Carry out immunoprecipitation and mass spectrometry to identify the chemical identity of cofactors, in collaboration with Professor P. Barran, University of Manchester.
- Develop and refine techniques for producing alpha‑synuclein folds in vitro, in cells and in animal models, and analyse these folds using cryo‑EM.
- Collaborate closely with structural biology teams and contribute to interdisciplinary research efforts.
Qualifications
- A PhD in a relevant subject or due to complete a PhD within 6 months is necessary.
- Experience in generating experimental models of amyloid formation and/or cryo‑EM or cryo‑ET.
- Good communication skills and the ability to work effectively both independently and in a group.
Benefits
- Defined benefit pension scheme.
- Holiday entitlement of 40.5 days per annum (including bank holidays and privilege days).
- Generous employee discount scheme.
- Training and development opportunities, including support toward role‑related qualifications.
Equality, Diversity and Inclusion
We actively support equality, diversity and inclusion in all our activities, processes and culture. We encourage applications from all sections of society. The LMB particularly welcomes women, minority ethnic and disabled candidates to apply for this vacancy as they are currently under‑represented. We are a disability inclusive employer and encourage disabled people to apply for this role. You are very welcome to contact us for information about the application process and any adjustments you may require.
Closing date: 31 May 2026.
Final appointments will be subject to a pre‑employment screening.
This role qualifies for endorsement by UKRI for a UK Global Talent Visa, for which the successful applicant is likely to be eligible to apply. Immigration costs (visa and health surcharge) can be reclaimed from UKRI after taking up the post (terms and conditions apply).
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