Lead Bioprocess Engineer – Scale-Up & Pilot Operations
Location: Somerset, UK (site-based)Type: Full-time
We are seeking an experienced Lead Bioprocess Engineer to lead the scale-up and industrialisation of an innovative bioprocess platform. This role combines technical leadership with hands‑on delivery, focusing on translating early‑stage science into pilot‑scale and commercially viable processes.
The Role
You will take ownership of bioprocess development and scale‑up activities, working closely with R&D, engineering and operations teams to move processes from lab through to pilot and beyond. A strong on‑site presence is essential, and you will be actively involved in running experiments, troubleshooting processes and optimising performance.
- Leading end‑to‑end scale‑up activities, from bench through pilot‑scale demonstration
- Translating cell culture and tissue engineering processes into scalable manufacturing solutions
- Taking a hands‑on role in process optimisation, troubleshooting, and system improvements across both unit operations and the wider platform
- Designing and overseeing scale‑down models and experimental plans to support robust scaling strategies
- Driving improvements in process efficiency, cost of goods, and environmental performance
- Ensuring appropriate process documentation, validation and technical standards are maintained
- Collaborating with internal teams and external partners to support technology development and delivery
- Managing and developing a team of engineers and scientists (3‑5 direct reports)
About You
You will bring a strong combination of technical depth, practical experience and leadership capability, with a clear track record in bioprocess scale‑up and industrial biotechnology.
Key Requirements
Advanced qualification in bioprocess, biochemical or chemical engineering
Extensive industry experience in bioprocess development and scaling
Proven track record working with bioreactors and associated unit operations from bench to pilot scale
Strong understanding of upstream and/or downstream processing, including troubleshooting and optimisation
Experience with CIP/SIP, contamination control and operational challenges in bioprocess environments
Demonstrated experience in leading teams and delivering complex technical programmes
A practical, hands‑on mindset, comfortable working directly with equipment and processes on‑site
A proactive, can‑do attitude, with the ability to solve complex problems and adapt in a fast‑paced environment
Why Apply?
This is an opportunity to play a central role in scaling a novel bioprocess technology, combining technical leadership with hands‑on engineering and science. You will work in a collaborative, innovation‑driven environment where your experience will directly influence the transition from R&D to real‑world production.
If you are a technically strong bioprocess expert who enjoys being close to the process, leading teams and delivering scale‑up in practice, this role offers a highly impactful next step.
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