Senior Scientist – Cancer Biology

We are partnered with an immuno-oncology focused biotech in Oxford seeking to hire a Senior Scientist with expertise in Cancer Biology. This role requires a PhD in a relevant field. Prior industry experience is highly desirable and familiarity with bioinformatics is a plus.

Responsibilities

• Contribute to a collaborative, high-integrity biotech research environment with strong standards for documentation, reproducibility, and compliance
• Support and help shape translational research strategy across early-stage discovery programmes in collaboration with a small multidisciplinary team
• Design, execute, and optimise in vitro experimental systems including 2D and organoid-based models
• Develop and refine assays for evaluating cell viability, cytotoxicity, and molecular readouts including sequencing-based methods
• Troubleshoot technical and scientific challenges to ensure high-quality, decision-enabling data generation
• Analyse, interpret, and present experimental results to guide project direction and progression
• Maintain compliance with internal SOPs and regulatory requirements, including mandatory training

Requirements

• Extensive experience handling human epithelial and cancer cells
• Experience in culture and expansion of primary epithelial cells
• Strong expertise in genetic manipulation of epithelial and cancer cells
• Experience developing cellular assays for viability, proliferation, and cytotoxicity studies
• Ability to design and perform qPCR, ELISA, and flow cytometry experiments
• Experience in immunofluorescence staining and microscopy
• Experience growing primary cancer cells in culture
• Experience developing and maintaining organoid models is highly desirable
• Prior experience with real-time imaging systems (e.g. Incucyte) and familiarity with RNA/DNA sequencing

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