Principal Scientist – LC-MS/MS Bioanalysis (PK/PD, Complex Modalities)

Role Overview

We are seeking a Principal Scientist – LC-MS/MS Bioanalysis (PK/PD, Complex Modalities) to act as a subject matter expert across LC-MS/MS bioanalytical programmes supporting PK and PD studies. This role provides scientific leadership across multiple studies, focusing on complex problem-solving, assay strategy, and client engagement.

Key Responsibilities

• Provide scientific leadership and SME support across LC-MS/MS studies
• Lead troubleshooting of complex analytical challenges, including matrix effects, sensitivity limitations, and assay robustness
• Advise on method development, optimisation, and validation strategies
• Support study teams in resolving technical issues and ensuring consistent assay performance
• Contribute to client interactions, including scientific discussions, data interpretation, and method justification
• Support proposals, bid defences, and scientific strategy discussions
• Mentor and support development of laboratory scientists

Technical Expertise

• Strong knowledge of LC-MS/MS theory, including triple quadrupole and HRMS systems
• Experience with sample preparation techniques such as SPE, LLE, protein precipitation, and hybrid workflows
• Deep understanding of quantitative bioanalysis, including calibration strategies, selectivity, and matrix effects

Experience with Complex Modalities

• Peptides and proteins
• Oligonucleotides
• Antibody-drug conjugates and related conjugates

Regulatory and Client Experience

• Extensive experience working under GLP and GCP
• Strong understanding of regulatory guidance (FDA, EMA, MHRA, M10)
• Experience supporting audits and regulatory inspections
• Proven ability to lead scientific discussions with clients and defend analytical approaches and data
• Ability to communicate complex technical issues clearly and challenge client assumptions where appropriate

Qualifications and Experience

• PhD in Analytical Chemistry or related field, or MSc with significant industry experience
• 10 to 15 or more years of LC-MS/MS bioanalysis experience
• Demonstrated expertise in method development, validation, and advanced troubleshooting

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