A unique opportunity to undertake a 2-year clinical fellowship based between two world leading Phase I units, year 1 spent at The Christie NHS Foundation Trust Manchester, UK, year 2 moving to The Peter MacCallum Cancer Centre Melbourne, Australia. We are seeking an ambitious and innovative individual with an interest in early phase clinical trials and research.
With consultant oversight you will be responsible for seeing new referrals, follow‑ups and managing patients throughout all aspects of their trial experience. There is an opportunity to undertake a postgraduate MD degree fully funded and co‑supervised by colleagues at The Christie and Peter Mac via the University of Manchester.
The position is suitable for those on a specialist oncology training pathway; preference will be given to those who are towards the end or have completed this, and who wish to gain further experience in experimental medicine, Phase I trials, first‑in‑human trials, clinical pharmacology trials and translational research.
Salary will be on The Christie and Peter Mac scales in line with appropriate clinical experience. Candidates are encouraged to discuss the remuneration package ahead of application. We anticipate the fellowship commencing in Manchester between Summer 2026 and February 2027 with some flexibility.
Please note interviews are likely to be outside of normal UK working hours to facilitate a joint interview panel between The Christie and PMCC.
Main duties of the job
The portfolio includes a diverse range of clinical research trials. Following training, you will be expected to participate in these studies as a sub‑investigator. Trials may include phase I trials of small‑molecule inhibitors, next‑generation chemotherapy trials, combination/multi‑modality phase I trials, advanced therapy trials, molecular characterisation/translational studies and radiotherapy trials.
You will be involved in managing all aspects of trial patients (in outpatient and inpatient settings) across a diverse range of solid tumours, through new patient consultation, consent, screening and follow‑up appointments.
You will attend safety review committee meetings to discuss trial patients and will liaison closely with the Principal Investigators. In addition, you will interface with external stakeholders such as CROs and pharmaceutical sponsors.
You will attend monthly molecular tumour board meetings to discuss trial patients and to agree opportunities for patients to enrol in early phase trials.
You will undertake administrative duties associated with the care of our patients. You will be given opportunities and encouraged to be involved in the development and planning of new studies.
There is potential to present your research work and you will be expected to be involved in writing papers and reviews. You will also undergo an annual appraisal.
About us
The postholder will contribute to the delivery of high‑quality consultant‑led care across seven days. This includes participation in planned weekend and weekday clinical activity to support safe, timely decision‑making and continuity of care for patients.
The Christie is one of Europe’s leading cancer centres, treating over 64 000 patients a year. We are based in Manchester and serve a population of 3.2 million. We provide radiotherapy through one of the world’s largest radiotherapy departments, chemotherapy on site and through 14 other hospitals, highly specialist surgery for complex and rare cancers and a wide range of support and diagnostic services. We are an international leader in research and run one of the largest early clinical trial units in Europe with over 300 trials a year.
Peter Mac (Melbourne) is home to the largest grouping of cancer researchers in Australia, who work alongside specialist teams to deliver exceptional care and drive groundbreaking research. It is recognised for its extensive clinical trial capabilities, supported by the Parkville Cancer Clinical Trials Unit, Australia’s largest cancer trials unit, which specialises in first‑human trials. Its Early Drug Development programme plays a key role in advancing new therapies from discovery to patient care. Note, that the full job description and role for the second year of the fellowship will be provided and facilitated through The Peter MacCallum Cancer Centre.
Job description
Job responsibilities
- Recruitment as a Senior Clinical Fellow in the Experimental Cancer Medicine Team; conduct responsible clinical duties across The Christie and Peter MacCentre.
- Participate in a diverse range of clinical research trials as a sub‑investigator.
- Manage trial patients from new consultation through follow‑up appointments, largely in outpatient setting with some inpatient cover; attend 4‑5 trial outpatient clinics per week.
- Attend safety review committee meetings (usually remotely) and liaise with trial Principal Investigators and the trial team across the Trust.
- Attend monthly molecular tumour board meetings to discuss patients and identify trial enrolment opportunities.
- Perform administrative duties and support development and planning of new studies.
- Present research work and contribute to writing papers and reviews.
- Undergo an annual appraisal and maintain level of professional development consistent with Royal College expectations.
- Contribute to undergraduate teaching of medical students on oncology topics and postoperative teaching on postgraduate and junior doctor education.
- Participate in clinical governance, maintain up‑to‑date protocols and guidelines, and support audit projects.
Person Specification
Qualifications
Essential
- In specialist oncology training at least at ST3 (or international equivalent)
- Registered with the GMC
- Evidence of productive ethical research relevant to oncology
Desirable
- Certificate of Completion of Training (CCT) in Medical or Clinical Oncology or equivalent; Good Clinical Practice; Advanced Life Support; higher degree in cancer research.
- Recent publications in peer‑reviewed journals and conference presentations.
- MRCP or equivalent.
Circumstances – Domicile
Essential
- Occupational Health clearance
- Enhanced CRB clearance
Experience
Essential
- Experience in general oncology and internal medicine
- Research/trials experience
- Evidence of clinical leadership skills
- Experience of developing, supervising and delivering audit projects
- Experience in teaching undergraduates
Desirable
- Experience in Phase I trials
- Experience teaching postgraduates
- Teaching qualification
Personal Skills
Essential
- Evidence of clinical skills.
- Excellent written and oral communication, flexibility, commitment and teamwork with colleagues and staff in the department; ability to work under pressure and motivate staff.
Desirable
- Demonstration of excellent communication skills.
Working Hours
Weekend working will consist of clinical activities that are scheduled in advance and reviewed where required. The role does not require participation in the on‑call rota, but out‑of‑hours and weekend shifts may be occasionally required to provide care to trial patients.
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