Principal Scientist (DMPK)
Permanent
Cambridge
A leading biotech organisation is seeking a Principal Scientist with deep DMPK and quantitative pharmacology expertise to support oncology-focused discovery and early development programmes.
You will define and drive translational DMPK strategies across the pipeline, applying mechanistic modelling and pharmacology insight to guide decision-making from lead optimisation through to IND. Working cross-functionally, you will play a key role in shaping programme direction and ensuring high-quality progression of assets toward the clinic.
Key Responsibilities:
- Define and implement translational DMPK strategies across multiple programmes, from lead optimisation to clinical candidate selection.
- Develop and apply PK/PD, PBPK, and other mechanistic models to inform dose, schedule, and exposure-response relationships.
- Integrate in vitro, in vivo, and in silico data to support decision-making and improve translational confidence.
- Partner closely with chemistry, biology, toxicology, and clinical teams to guide programme strategy.
- Contribute to human dose prediction and support first-in-human study design.
- Provide scientific leadership within project teams and across the wider DMPK function.
- Oversee external collaborations and CRO activities where required.
- Mentor and support development of junior scientists within the team.
- Present data and strategic recommendations clearly to internal stakeholders and external collaborators.
Key Requirements:
- PhD (or equivalent experience) in a relevant scientific discipline, with significant industry experience in drug discovery and early development.
- Strong expertise in DMPK and quantitative pharmacology, including PK/PD and PBPK modelling.
- Experience applying modelling and simulation to support candidate selection and clinical translation.
- Familiarity with tools such as Phoenix WinNonlin, NONMEM, MATLAB, or similar.
- Proven ability to work in cross-functional project teams and influence decision-making.
- Experience supporting programmes from discovery through to IND/early clinical development.
- Excellent communication skills and the ability to translate complex data into clear insights.
- Prior leadership or mentoring experience is desirable.
Apply now by attaching your CV in Word, or contact Paige Keenan (paige.keenan@srgtalent.com) for further information about this opportunity.
…